Pfizer Inc. has advised the European Union that any threat to ban vaccine exports may risk pushing production off course if the U.K. retaliated by withholding key ingredients for its Covid-19 shot. Meanwhile, Paris went into a third lockdown, Poland closed shopping centers and Germany approached a threshold that could trigger more restrictions.

Pakistan’s Prime Minister Imran Khan has tested positive and is self-isolating, the country’s health minister said. Brazil reported record new cases for the second day this week. The Philippines and Hungary also saw daily infections reach all-time highs.

In Germany, Chancellor Angela Merkel pledged to accelerate the vaccination drive, seeking to recover from the suspension of the AstraZeneca shot.

Key Developments:

• Global Tracker: Cases pass 122.4 million; deaths top 2.7 million
• Vaccine Tracker: More than 420 million shots given worldwide
• How Europe injected doubt into a vaccine the world needs
• U.S. states throw open vaccine eligibility before May 1
• Colleges turn arenas into mass vaccination sites for students
• Why the Fed is ending its big Covid break for banks: QuickTake

Subscribe to a daily update on the virus from Bloomberg’s Prognosis team here. Click CVID on the terminal for global data on cases and deaths.

Pfizer Warns About Disruption (5:52 p.m. HK)

The drugmaker spoke with the EU as tensions over vaccine supplies grow between the U.K. and the bloc. Manufacturing of lipids -- fatty material used to deliver the genetic material at the heart of Pfizer and German partner BioNTech SE’s vaccine -- takes place at a secret location in the U.K. and are sent to the EU where the shots are completed.

“We have been clear with all stakeholders that the free movement of goods and supply across borders is absolutely critical to Pfizer and the patients we serve,” a spokesman for Pfizer said in an emailed statement. The Telegraph first reported the discussions Friday.

Pakistan Prime Minister Tests Positive (5:46 p.m. HK)

Imran Khan is the latest head of government to contract the virus after U.K’s Boris Johnson, France’s Emmanuel Macron, Brazil’s Jair Bolsonaro and former U.S. President Donald Trump. Khan is self-isolating at home, Health Minister Faisal Sultan said in a tweet.

European Cases Accelerate (5:30 p.m. HK)

Poland registered 26,405 new Covid cases in the last 24 hours, the second biggest daily increase this year, prompting the nation to shut down shopping centers. In Sweden, even if AstraZeneca vaccinations are resumed, chances are small that all adults will be fully vaccinated with two doses by June 30, vaccine coordinator Richard Bergstrom says in an interview with newspaper Svenska Dagbladet. Two health-care workers in Denmark were admitted with symptoms of blood clots within two weeks of their AstraZeneca shot and one has died, newspaper Ekstra Bladet reported. In the Czech Republic, there were signs of the pandemic easing with the lowest workday figure in more than a month for new infections.

Senegal Lifts Emergency (5:25 p.m. HK)

Senegal lifted a state of emergency, ending a nighttime curfew in the regions of Dakar and Thies in an attempt to bolster an economy hit hard by restrictions on movement during a first wave of the virus. The decision comes as Senegal reached the threshold of 1,000 coronavirus-related deaths.

German Rate Close to Restriction Threshold (4:46 p.m. HK)

Germany’s seven-day incidence rate rose to 99.9 per 100,000 people on Saturday, the highest in almost two months, according to the country’s RKI health institute, and close to the threshold at which Chancellor Angela Merkel and regional officials agreed to reimpose restrictions.

On Monday, Merkel and state leaders will discuss whether restrictions should be extended into April or even tightened, rather than eased as suggested by the government at the start of the month, as the country faces a virus resurgence that is affecting all of Europe. Merkel said on Friday that Germany will accelerate its Covid-19 vaccination drive in April, after regulators gave the all-clear for the AstraZeneca shot.

Philippines Daily Cases Reach Record (4:14 p.m. HK)

The Philippines, home to Southeast Asia’s second-worst outbreak, reported a record 7,999 coronavirus cases on Saturday, bringing the total to more than 656,000. The government has asked state offices not engaged in critical services to reduce operations from March 22 to April 4.

Earlier, it ordered dine-in restaurants in areas including Manila to operate at half capacity until April 4. It also limited conferences and religious gatherings, and shut museums and other tourist attractions.

Hungary’s Daily Cases, Deaths Hit Record (4:12 p.m. HK)

Hungary reported a record 227 daily deaths from Covid-19 as the country struggles to curtail infections despite having the second-highest vaccination rate in the European Union. New cases grew by an unprecedented 11,132.

The government on Friday announced the extension of a lockdown -- which would have expired on Monday and which forced most stores to close -- by at least another week.

Sri Lanka Approves Sinopharm Vaccine (3:21 p.m. HK)

Sri Lanka approved the Sinopharm Covid-19 vaccine for emergency use, Xinhua reported, citing a government minister. It’s the third vaccine to gain approval in the country, following the AstraZeneca and Sputnik V shots.

Australia and New Zealand Discuss Corridor (8:05 a.m. HK)

Australia and New Zealand could allow two-way travel between them without requiring quarantine within weeks, the Australian Financial Review reported, citing Australia’s trade and tourism Minister Dan Tehan.

Chicago Hospital Reported to Give Vaccines Offsite (7:57 a.m. HK)

Loretto Hospital, a safety-net institution in the west side Chicago neighborhood of Austin, is facing heat for reportedly administering vaccinations offsite including at the Trump Tower, according to local news reports.

The hospital’s board, which includes elected officials, says the events “stemmed from a sincere desire to vaccinate as many eligible Chicagoans as possible – especially people of color.” But it added that the actions “fall outside the scope of the Loretto Hospital’s core mission,” and two executives have been reprimanded, according to a statement Friday.

The city “will not tolerate providers who blatantly disregard the Chicago Department of Public Health’s distribution guidelines,” Chicago Mayor Lori Lightfoot said in a statement Thursday.

Paris Goes Under Lockdown (7:24 a.m. HK)

A third lockdown affecting several French regions including the Paris area went into effect at midnight on Friday. Only essential businesses and schools will stay open, with the restrictions due to remain in place for four weeks. Like the rest of the country, the French capital has been under a nightly curfew since mid-January with cafes, restaurants, bars and theaters closed. But the infection rate has climbed nonetheless, and hospitals are under increasing strain.

More U.S. States Open Shots to All (6:40 a.m. HK)

At least three more states said they would open eligibility for vaccines to people 16 years and older before President Joe Biden’s May 1 deadline. More than a dozen other states have said they would begin vaccinating all adults by then.

North Dakota said it would expand eligibility by March 29. Maine and Vermont said they would do so by April 19.

Outbreak Reported to Hit Mar-a-Lago (6:11 a.m. HK)

Mar-a-Lago, former President Donald Trump’s Palm Beach club, is partially closed due to an outbreak of Covid-19, the Associated Press reported Friday, citing people familiar with the matter, including a club member who was notified by phone.

Some workers were quarantined and a section had been closed off for a short period, according to one person, who declined to be named in the AP report.

The Trump Organization didn’t immediately respond to a request to independently confirm the report, nor did Mar-a-Lago Managing Director Bernd Lembcke. A woman who answered the phone at the club declined to comment and wouldn’t give her name.

Brazil Cases Break Record (5:42 p.m. NY)

Brazil reported a record number of new cases for the second time this week as officials scramble to halt another deadly wave of the virus. On Tuesday, the nation also reported a record number of fatalities.

Another 90,570 new infections were reported on Friday, pushing the number to 11,817,390. The Health Ministry also reported 2,815 deaths in the last 24 hours, totaling 290,314.

The Brazilian government signed contracts to purchase 100 million doses of the Pfizer/BioNtech vaccine and 38 million doses of the single-dose shot developed by Janssen.

Biden Says Vaccine Goal May Double (4:39 p.m. NY)

President Joe Biden said the U.S. may be able to administer 200 million doses of vaccine in the first 100 days of his presidency, twice the initial goal that he reached Friday.

The U.S. “may be able to double it” if it keeps its current pace of vaccinations, Biden told reporters at the White House when asked Friday about his 100-million shot goal. “But we’ve met the goal and continue to move forward.”

Biden has said he may make public a new goal next week.

NYC to Expand In-Person Schooling (3:10 p.m. NY)

New York City schools will expand in-person instruction to include more students after guidance from the CDC recommended three feet of separation between children would be sufficient to prevent contagion in classrooms. The U.S.’s largest school system has been operating under a hybrid schedule in elementary and middle-schools, along with rigorous testing requirements.

— With assistance by Ian Fisher, Stephen Treloar, Ian Wishart, Suzi Ring, Marthe Fourcade, Lars Erik Taraldsen, Anton Wilen, Jeanette Rodrigues, Alex Vasquez, Rachel Gamarski, Jonathan Levin, Gaspard Sebag, Shruti Singh, Siegfrid Alegado, Zoltan Simon, Mariajose Vera, Ania Nussbaum, Wojciech Moskwa, Love Liman, Katarina Hoije, and Krystof Chamonikolas